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EPA has produced a vast collection of science-related documents to support pesticide registration decisions. Below you will find a subset of documents that, generally, have been requested by the public through the Freedom of Information Act (FOIA) process. Each of these documents has been reviewed to ensure that any proprietary information is not included.

If you wish to obtain a document that is not currently posted, you may do so by filing a FOIA request.

   
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  • 1 - 50 of 156
DateTitleAuthorOrganizationMRID
-Effects Determination for Malathion and the Delta Smelt and California Tiger Salamander
 Additional ES Files Additional ES Files (California Red-legged Frog and other California Listed Species)
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-Effects Determination for Malathion and the California Red-legged Frog
 Additional ES Files Additional ES Files (California Red-legged Frog and other California Listed Species)
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-Effects Determinations for Malathion
 Additional ES Files Additional ES Files
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-DER #4. Malathion: 1-Year Chronic Oral Toxicity Study in Dogs. Tegeris Laboratories. 1987. MRID 40188501. HED Doc. No. 006349. (PDF, 17 pp, 931K)Toxicology Branch-40188501
-DER #17; Malathion: Metabolism Study in Sprague-Dawley Rats. Midwest Research Institute. 1989. MRID No. 41367701. HED Doc No. 007791. Registration Data removed from pages 10-18. (PDF, 18 pp, 489K)Toxicology Branch-41367701
-DER #12; Malathion: 21-Day Dermal Toxicity Study in Rabbits. MB Research Laboratories. 1988. MRID No. 41054201. HED Doc Nos. 008714 & 009385. (PDF, 22 pp, 1MB)Toxicology Branch-41054201
-DER #8; Malathion: Acute Delayed Neurotoxicity Study in Hens. Bio-Life Associates. 1988. MRID No. 40939301. HED Doc Nos. 007524, 008026. (PDF, 22 pp, 1MB)Toxicology Branch-40939301
-DER #13; Malathion: 13-Week Subchronic Inhalation Toxicity Study in Sprague-Dawley Rats. Bio-Research Laboratories (Canada). 1994. MRID No. 43266601. HED Doc No. 011516. (PDF, 26 pp, 2MB)Toxicology Branch-43266601
-DER #7a. Malathion: Range-Finding Developmental Toxicity Study in Rabbits. Food & Drug Research Laboratories. 1985. MRID No. 00152569. HED Doc. No. 007376. Registration Data removed from pages 6-26. (PDF, 26 pp, 173K)Toxicology Branch-152569
-DER #5. Malathion: 2-Generation Reproduction Study in Sprague-Dawley Rats. Bio/dynamics. 1990. MRID 41583401. HED Doc. No. 009365. (PDF, 28 pp, 1MB)Toxicology Branch-41583401
-DER #6. Malathion: Developmental Toxicity Study in Sprague-Dawley Rats. Argus Research Laboratory. 1989. . MRID No. 41160901. HED Doc. No. 008384. Registration Data removed from pages 13-28. (PDF, 28 pp, 674K)Toxicology Branch-41160901
-DER #7. Malathion: Developmental Toxicity Study in Rabbits. Food & Drug Research Laboratories 1985. MRID No. 00152569, 40812001. HED Doc. No. 007376. (PDF, 7 pp, 354K)Toxicology Branch-152569... [More]
-DER #2. Malathion: 18-Month Carcinogenicity Study in B6C3F1 Mice. International Research & Developmental Corp. 1994. MRID No. 43407201. HED Doc. No. 011455. Registration Data removed from pages 45-48 & 66-78. (PDF, 78 pp, 4MB)Toxicology Branch-43407201
-Recommended International Tolerances for Pesticide Residues (PDF, 4 pp, 247K)J. G. CummingsPetitions Evaluation Branch, FDA-
-Review of a 6(a)(2) and Follow-Up Data Submitted for Developmental Neurotoxicity and Acetylcholinesterase Studies in Rats [re malathion; see 12/14/2000 & 4/19/2001]. (PDF, 2 pp, 73K)Carmelita WhiteSRRD-
-DER #13a; Malathion: 2-Week (Range-finding) Inhalation Study in Sprague-Dawley Rats. MRID No. 44554301; 82-4. (PDF, 14 pp, 685K)Brian DementiToxicology Branch44554301
-Special Study, Effects on Cholinesterase in Adult & Juvenile CD Rats, Companion Study to Development Neurotoxicity Study 870.6300. Tox Review No. 0050550. MRID No. 45566201. (PDF, 22 pp, 2MB)Brian DementiToxicology Branch45566201
08/21/2007Malathion and Malaoxon: Follow-up Analysis of Acute Dose Comparative Cholinesterase Study Protocol PC Code: 057701. Barcode: DP# 342339. TXR No. 0054671 (PDF, 6 pp, 187K)Deborah SmegalRe-Registration Branch 2-
06/28/2007Malathion and Malaoxon: Review of Acute Dose Comparative Cholinesterase Study Protocol PC Code: 057701. Barcode: DP# 340518. TXR No. 0054632 (PDF, 9 pp, 275K)Deborah SmegalRe-Registration Branch 2-
03/30/2007Data Evaluation Record (DER) for Special Study: Repeat Dose Comparative Cholinesterase Study of Malathion and Malaoxon in Juvenile Rats. DP Barcode: D332783. TXR # 0054537. (MRID Nos. 46822201, 46821703) (PDF, 19 pp, 695K)Gerome BurkeToxicology Branch46821703... [More]
04/11/2005Benchmark dose analysis of brain and RBC data from the malathion comparative cholinesterase study in juvenile and adult rats (MRID No. 45566201). TXR No. 0053251 (PDF, 59 pp, 152K)Anna LowitReregistration Branch 245566201
11/19/2004Malathion use as a mosquitocide and potential risk to listed salmonids. DP Barcode: 308617 (PDF, 9 pp, 661K)Norman BirchfieldEnvironmental Risk Branch I-
11/09/2004D292658: Malathion (057701) Amendment 1 to comparative cholinesterase inhibition study in adult and juvenile rats (MRlD 46005001). TXR No. 0052129 (PDF, 13 pp, 547K)Brian DementiToxicology Branch-
04/02/2003Efficacy Review - Ortho Malathion 50 Insect Spray (PDF, 4 pp, 612K)Joanne EdwardsInsecticide-Rodenticide Branch RD45829601... [More]
11/08/2002Malathion: Updated Revised Occupational Exposure and Risk Assessment for the Interim Reregistration Eligibility Decision (IRED) Document. (DP Barcode: D286796; EPA MRID Nos.: 45005910, 45491901, 45138202, 45491902, 45138201, 45469501) (PDF, 440 pp, 20MB)Jack ArthurRegistration Action Branch 345005910... [More]
08/22/2002D282204. Malathion (057701) Developmental neurotoxicity data reviews: 1) developmental neurotoxicity study in rats 2) comparative cholinesterase inhibition study in adult and juvenile rats 3) dose range-finding developmental neurotoxicity in rats. (PDF, 100 pp, 8MB)
 Additional Files Attachments
Susan MakrisToxicology Branch-
04/22/2002DER #7b. Malathion: Registrant Comments on Agency review of prenatal developmental Toxicity study in rabbits (MRID No. 45626801) Supplemental to MRID Nos. 00152569 & 40812001. Tox Review No. 0050549. (PDF, 9 pp, 672K)Susan MakrisToxicology Branch152569... [More]
04/19/2001Review of a February 13, 2001 FIFRA 6(a)(2) Submission of Preliminary Data from a Developmental Neurotoxicity Study on Malathion Performed in CD Rats. Tox review 014544. (PDF, 14 pp, 1MB)Brian DementiToxicology Branch-
12/14/2000Review of FIFRA 6(a)(2) Data Submission for a Dose Range- Finding Study in Sprague-Dawley Rats Intended to Provide Guidance for Dose Selection for the Definitive Developmental Neurotoxicity and Acetylcholinesterase Studies... Tox review 014413 (PDF, 9 pp, 788K)Brian DementiToxicology Branch-
09/12/2000DER #4a. Malathion: 28-day oral toxicity study in beagle dogs. (MRID 45077703); Review of 28-Day Oral Toxicity Study of Malathion in Beagle Dogs (MRID No. 45077703); Recommendations for Further Testing in Dogs. Tox Review No. 014336. (PDF, 8 pp, 590K)Brian DementiToxicology Branch45077703
02/10/2000Malathion - Report of the Cancer Assessment Review Committee Attached: 2/2/2000 Final Cancer Assessment Document; Evaluation of the Carcinogenic Potential of Malathion. MRID No. 43975201. Tox review 013991. (PDF, 54 pp, 4MB)Brian DementiToxicology Branch43975201
01/18/2000DER #14b; Malathion: Published Study; Ehrich, M., Shell,L., Rozum, M., and Jortner, B.S. (1993) Short-term clinical & neuropathologic effects of cholinesterase inhibitors in rats. J. Am Coll. Toxicol. 12(1), 55-68 (MRID No. 45045001) TXR0050532. (PDF, 16 pp, 1MB)Toxicology Branch-45045001
11/18/1999Malathion: Study Pathologist's Responses (MRIDs 44837001, 44970601, 44970501) to Health Effects Division's Questions on the Nasal Tissue Histopathology Re-evaluation (MRID 44782301) of the Combined Chronic Toxicity/Carcinogenicity Study in the F344 Rat� (PDF, 14 pp, 883K)Brian DementiToxicology Branch44782301... [More]
11/08/1999Malathion: Preliminary Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Chemical No. 057701. Case No. 0248. Barcode D255364. Tox review 013873 (PDF, 72 pp, 5MB)Paula DeschampReregistration Branch 2, HED-
11/03/1999MALATHION: Preliminary Dietary Risk Assessment (Revised) (PDF, 15 pp, 912K)Richard GriffinReregistration Branch II, HED-
10/06/1999MALATHION: Preliminary Dietary Risk Assessment (PDF, 15 pp, 1MB)Richard GriffinReregistration Branch II, HED-
05/27/1999Review of the Histopathology Re-Assessment of Nasal Tissues for the Malathion 24-Month Oral (Dietary) Combined Toxicity/ Carcinogenicity Study in the F344 Rat (MRID 44782301). Pages 26-81 removed, registrant data. Tox review 013719. (PDF, 81 pp, 2MB)Brian DementiToxicology Branch44782301
05/05/1999Review of Histopathology Assessment of Nasal Tissues for the Malathion 18-Month Oral (Dietary) Carcinogenicity Study in Mice (MRID: 44733501; 44792301). Pages 14-25 removed, registrant data. Tox review 013722. (PDF, 25 pp, 1MB)Brian DementiToxicology Branch44733501... [More]
02/12/1999Cancer Assessment Review Committee Meeting on Malathion. Pages 187-190, 208-219 removed, registrant data. (page 2: 2/12/99; William Burnam; Additional Malathion Information for... Cancer Peer Review; page 3: 9/8/97; Jess Rowland; Cancer Assessment� (PDF, 276 pp, 19MB)Sanjivani DiwanHealth Effects Division-
02/11/1999Supplemental Information for the Cancer Assessment Review Committee Meeting Scheduled for February 24, 1999 to Resume Evaluation of the Malathion Carcinogenicity Database. Pages 13-84, 143-149 removed, registrant data. (PDF, 154 pp, 5MB)
 Additional Files Attachments
Brian DementiToxicology Branch-
01/08/1999Malathion: PC Code 057701. Case 0248. Magnitude of Residues in/on avocados, beans (dry), blueberries, grapes, grasses, onions (dry bulb), onions (green), rice, spring wheat, winter wheat (OPPTS 860.1500) & an orange processing study (OPPTS 860.1520). (PDF, 55 pp, 3MB)
 Additional Files Attachments
Manying XueChemistry & Exposure Branch I-
12/22/1998MALATHION: - RE-EVALUATION A Report of the Hazard Identification Assessment Review Committee. (PDF, 152 pp, 6MB)Jess RowlandHazard Identification Assessment Review Committee-
12/01/1998Review of Pathology Working Group Report (PWG) Peer Review of Proliferative Lesions of the Liver in Male B6C3F1 Mice in an 18-Month Oral (Dietary) Oncogenicity Study in Micce of Malthion. MRID 44554901. Tox Review 013721. (PDF, 23 pp, 2MB)Brian DementiToxicology Branch44554901
11/05/1998Malathion: PC Code 057701. Registration Case 0248. Magnitude of Residues in Alfalfa, Clover & Cottonseed (OPPTS 860.1500) Processing Studies in Grapes, Cottonseed, Rice & Field Corn (OPPTS 860.1520). MRID Nos. 43546101, 43545201, 43596601, 43577401, 4358 (PDF, 43 pp, 3MB)Manying XueChemistry & Exposure Branch I43546101... [More]
09/22/1998EFED RED Chapter for Malathion PC Code 057701; Case No. 818961 DP Barcodes: D238903 and D238906 and D238904 (PDF, 158 pp, 11MB)Brian MontagueEnvironmental Risk Branch-
08/18/1998Review of Malathion Incident Reports. (PDF, 39 pp, 3MB)Jerome BlondellChemistry & Exposure Branch-
07/13/1998Malathion: PC Code 057701. Case 0248. Magnitude of Residue of Malathion & malaoxon in/on Winter Wheat Grain & its Processed Commodities. MRID No. 43510501. (PDF, 8 pp, 492K)Manying XueChemistry & Exposure Branch I43510501
05/26/1998Malathion: PC Code 057701. Case 0248. Magnitude of Residues of Malathion & Malaoxon in/on Stored Grains &Processed Commodities. (OPPTS 860.1520). MRID Nos. 436661401 & 43666801. (PDF, 18 pp, 1MB)Manying XueChemistry & Exposure Branch I43661401... [More]
02/18/1998DRES Analysis for Malathion '... Please perform a chronic and acute DRES analysis for malathion using additional PDP information provided...' (PDF, 2 pp, 78K)Martha LamontRegistration Action Branch I-
12/17/1997Malathion - Report of the Hazard Identification Assessment Review Committee Tox review 012440. (PDF, 53 pp, 3MB)Jess RowlandScience Analysis Branch HED-
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